education is the key - many people assume that horses need to be negative across the board to be considered viable breeding CANDIDATES. i DISAGREE. it depends on what they carry and if it is in the recessive form or not - as even one copy passed on will not affect the foal in a negative manner.
diseases in many forms have been present in nearly every breed of horse for many, many years. now with new technology available we can better the breed by testing and not crossing two individuals with the same trait - and potentially produce a problem or heartbreak from loss.
recessive means that the gene is in one copy form, and the horse can be a carrier without causing debilitating inherited abnormalities - such as gbed and olws.... the problem arises when two positive, recessive carriers are bred together and can create a double positive(homozygous) form of the disease.
horses bred or considering to be bred to krayola will need to be tested for olws and gbed before approval. -------------------------------------------------------------------------------------------- All information derived from www.animalgenetics.com and is copyright. thank you ~
Genetic Specifics ~ What about all this "Five Panel Testing" going on? AQHA has partnered with University of California - Davis to provide genetic testing for stallions(or mares) with the 5 known genetic diseases that affect quarter horses(and paints and some other breeds, but we won't go there and confuse you just yet)
So, What are these diseases? I've added a link for specifics if you would like to dig deeper than my description.
Lets go with the first one, the only one that "krayola" is a carrier for, its called
GBED, which stands for "Glycogen Branching Enzyme Deficiency" Syndrome. If you have a carrier, as he is, they show no signs, and have no symptoms or issues to deal with at all. But, the problem arises when you breed two carriers together. Not all the time, but sometimes when tow carriers are bred together it makes it difficult to conceive, which is a good thing, as if the foal is brought to term it unfortunately does not have the proper genes to process glucose, or sugar, and they won't live. You can read more about GBED by clicking HERE. So, test your mare(or we can test for you in a few days after arrival) if you are considering breeding to "krayola". Now, lets go into the others that he DOES NOT carry: ------------------------------------------------------------------------- Herda is also a genetic recessive disease in that you have to have two carriers bred together to have an affected foal. Herda mainly affects the Poco Bueno line, and is linked to line/in breeding that was seen many years ago. Affected horses are missing a link that "glues" the skin together and the skin of the affected horse is loose and tears easily. These horses are usually euthanized and not capable of leading a pain free life with the condition. Think of it like having skin draped over the body with nothing for it to hold onto. It moves around and slides and can rip and tear. You can read more about Herda HERE ------------------------------------------------------------------------- HYPP aka Hyper Kalemic Periodic Paralysis - this is found typically with horses that decend from the AQHA stallion "Impressive". It is a disease that even a single carrier can exhibit symptoms and some go along without any issues. If the horse has a line that goes to Impressive that is tested NN, it means they do not and can not carry even one copy of the disease. If they go to a line that is NH, that means they can or might carry a copy and be a NH horse themselves. CB has no impressive in his pedigree to worry about HYPP at all. You can click HERE to learn more about HYPP ------------------------------------------------------------------------- MH - also known as "Malignant Hyperthermia" information can be seen HERE ------------------------------------------------------------------------- PSSM - "Polysaccharide Storage Myopathy" is similar in nature to HYPP, where a carrier can and usually will show signs of the disease, you can read about it HERE -------------------------------------------------------------------------------------------- Frame Overo (LWO)
Description:Frame Overo is a highly desirable white pattern gene. All Frame Overo horses carry a single inherited copy of the the Ile118Lys EDNRB mutation. This mutation causes pigment loss, producing white markings on certain areas of the horse. While the mutation produces visually desirable horses, it is also linked to a fatal condition known as Lethal White Overo or (LWO), whereby a foal is born almost pure white in appearance, and dies within its first few days of life. Correct breeding can avoid this occurrence.
LWO occurs when a horse inherits two copies of the mutated gene, one from both parents. Whereas horses with just one copy of the gene will live normally and exhibit the desirable pattern. A horse with two copies of the mutated gene will suffer intestinal abnormalities caused by undeveloped nerves of the foal's digestive system. These animals die within the first 72 hours of being born and are typically euthanized sooner for humane reasons.
Frame Overo horses which carry just a single copy of the gene, will pass one copy of it to their foals approximately 50% of the time when bred. Therefore, when breeding an Overo horse to a solid non-Overo horse, the foal can only inherit one copy. However, if two Overo horses are bred together they could potentially BOTH pass the Overo gene to the foal, meaning it inherits two copies. Horses which inherit two copies of Frame Overo will suffer the Lethal White condition. Proper mating must be carried out to ensure that two frame Overo horses do not breed. This will prevent any risk of the foal inheriting two copies of the mutated gene.
Test Results:Animal Genetics offers DNA testing for Frame Overo. The genetic test verifies the presence of the Ile118Lys EDNRB mutation, and presents results as one of the following: